Thermo Fisher Scientific GluR1 (GluA1) (extracellular) Polyclonal Antibody, Atto 594

Thermo Fisher Scientific GluR1 (GluA1) (extracellular) Polyclonal Antibody, Atto 594

Applications and Tested Dilution

• Immunocytochemistry (ICC/IF): 1:25

Species Reactivity

• Human
• Mouse
• Rat

Product Specifications

Product Specific Information

Reconstitution: Add 50 µL double distilled water (DDW), depending on sample size.
The antibody ships as a lyophilized powder at room temperature. Upon arrival, store at -20°C.
Reconstituted solution can be stored at 4°C for up to 1 week. For longer storage, aliquot and keep at -20°C.
Avoid multiple freeze/thaw cycles. Centrifuge all antibody preparations before use (10,000 × g, 5 min).

Target Information

GluR1 (glutamate receptor 1) is an ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
Binding of L-glutamate induces a conformational change that opens the cation channel, converting the chemical signal into an electrical impulse.
The receptor desensitizes rapidly and enters a transient inactive state characterized by bound agonist.
In the presence of CACNG4, CACNG7, or CACNG8, GluR1 shows resensitization characterized by delayed current flux accumulation upon continued glutamate application.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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