Thermo Fisher Scientific Telomerase Binding Protein, P23 Polyclonal Antibody
Telomerase Binding Protein p23에 특이적인 Rabbit Polyclonal Antibody로, WB, IHC, ICC, ELISA 등에 사용 가능. Human, Mouse, Rat 반응성. Protein A로 정제된 액상 형태이며, 안정적인 저장 버퍼 구성으로 연구용에 적합.
- 카탈로그번호
- BS-1909R
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:400 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human Telomerase Binding Protein, P23 (amino acids 31–130) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Steroid receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate hormone. Prior to activation, steroid receptors associate with various proteins in both stable and transient forms.
Steroid receptor complex proteins include:
- Heat shock proteins (HSP70 and HSP90)
- Immunophilins (FKBP52, FKBP54, CyP-40)
- Additional proteins termed p23, p60, and p48
p23, along with HSP70, HSP90, and p60, forms a transient intermediate complex with progesterone receptor (PR). Cloned human p23 encodes a 160 amino acid protein highly conserved across species, with no homology to previously identified proteins. It is a highly acidic phosphoprotein featuring an aspartic acid-rich C-terminal domain and multiple potential phosphorylation sites.
In vitro studies suggest that p23 binds to HSP90 and is necessary for the association of HSP90 and CyP-40 with PR. Although its precise function remains unclear, p23 appears to play an important role in PR function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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