Thermo Fisher Scientific PD-L1/PDCD1LG1/CD274/B7-H1 (Cancer Immunotherapy Target) Monoclonal Antibody (PDL1/2741)
PD-L1 단백질에 특이적인 Mouse 모노클로날 항체로 암 면역치료 연구에 활용 가능. ELISA 및 Peptide Array 등 다양한 응용에 적합. 고순도 Protein A/G 정제, PBS 버퍼에 보존제 없음. 인간 PD-L1 (CD274) 타깃으로 T세포 반응 조절 연구에 유용.
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Applications
ELISA (ELISA)
- Tested Dilution: Assay-dependent
Peptide Array (Array)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | PDL1/2741 |
| Immunogen | Recombinant fragment of human CD274 protein (around aa39–191) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
Programmed death receptor ligand 1 (PD-L1, also called B7-H1) is a member of the B7 family. PD-L1 binds to its receptor PD-1, which negatively regulates T-cell receptor (TCR) signaling. Upon binding, PD-L1 decreases TCR-mediated proliferation and cytokine production. PD-L1 expression is abundant in many murine and human cancers and can be further up-regulated by IFN-gamma stimulation. Thus, PD-L1 plays an important role in tumor immune evasion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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