Thermo Fisher Scientific NAB2 Monoclonal Antibody (OTI5D10), TrueMAB
Human NAB2 단백질(aa 178-442)에 특이적인 마우스 단클론 항체로, Western blot에 최적화되어 있습니다. 동결건조 형태로 제공되며, PBS(pH 7.3, 8% 트레할로스) 버퍼에 보관합니다. 연구용으로만 사용 가능합니다.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5D10 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 178–442 of human NAB2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
Transcriptional control is regulated by interactions between DNA-bound transcription factors such as Egr-1/NGFI-A and coregulatory proteins like NAB (NGFI-A-binding proteins). The NAB family, including NAB1 and NAB2, acts as corepressors of Egr-1/NGFI-A.
Both proteins contain an N-terminal NAB conserved domain 1 (NCD1) for NGFI-A binding and a C-terminal NCD2 domain responsible for repressor function.
NAB2 is localized mainly in the nucleus and may regulate NGFI-A activity, cell division, differentiation, and apoptosis. It has a predicted molecular mass of 56 kDa and maps to chromosome 12q13.3–14.1, a region associated with several solid tumors, lipomas, and liposarcomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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