Thermo Fisher Scientific TRAIL-R2 (DR5) Chimeric Recombinant Rabbit Monoclonal Antibody (304)
인간 DR5(TRAIL-R2)를 특이적으로 인식하는 키메라 재조합 토끼 단클론 항체. Western blot, ICC/IF, Flow cytometry 등 다양한 어플리케이션에 사용 가능. Protein A로 정제된 액상 형태로 제공되며, 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | 1:1,000 |
| Flow Cytometry (Flow) | 1 µg/mL |
| ELISA | Assay-dependent |
| Functional Assay | Assay-dependent |
| Radioimmune Assay (RIA) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 304 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Immunogen
The antibody was raised in mice homozygous for both disrupted endogenous Ig heavy chain and k light chain, harboring a chromosome 14 fragment (SC20) containing a human Ig heavy chain locus and a human Igk chain transgene (KCo5). The mice were immunised against TRAIL-R1 and TRAIL-R2.
Target Family: TRAIL-R2 (DR5)
UniProt ID: O14763-1
Antigen Range: 1–2
Antigen Length: 440
Product Specific Information
The antibody is specific to human DR5.
Target Information
DR5 (Apo2, TRAIL-R2, TRICK2, KILLER) is a death domain-containing receptor for TRAIL that mediates TRAIL-induced apoptosis. It belongs to the TNF-receptor superfamily and contains an intracellular death domain. DR5 can be activated by TNFSF10/TRAIL/APO-2L, transducing apoptosis signals. FADD, a death domain adaptor protein, is required for DR5-mediated apoptosis. Two transcript variants encoding different isoforms and one non-coding transcript are known. Overexpression of DR5 induces apoptosis and activates NF-kappa-B. DR5 is highly expressed in lymphocytes and spleen. DR5 dysfunction is associated with diseases such as squamous cell carcinoma and diffuse infiltrative lymphocytosis syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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