Thermo Fisher Scientific Prostaglandin E Receptor EP2 Polyclonal Antibody, FITC
FITC 결합된 Rabbit Polyclonal 항체로 Prostaglandin E Receptor EP2를 검출. Western blot, IHC, ICC, ELISA 등 다양한 응용 가능. 인간 및 생쥐 반응성. 형광 최대치 498/517 nm, -20°C 암소 보관.
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Thermo Fisher Scientific Prostaglandin E Receptor EP2 Polyclonal Antibody, FITC
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| Immunocytochemistry (ICC/IF) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
| Immunomicroscopy (IM) | 1:50–1:200 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 300–350 on human Prostaglandin E2 receptor EP3 subtype |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Prostaglandins are produced by the metabolism of arachidonic acid. Prostaglandin E2 (PGE2) is one of the five physiologically significant prostanoids. Its wide range of physiologic and pharmacologic effects are mediated through binding to Prostaglandin E2 receptors (EP1, EP2, EP3, and EP4). These effects span immune, endocrine, cardiovascular, renal, and reproductive systems, as well as smooth muscle regulation.
PGE2 is abundant in the brain, where it plays a role in neural functions and inflammation mediation. EP2 receptors are G-protein coupled receptors (358 amino acids) that stimulate adenylyl cyclase via Gs coupling and do not undergo PGE2-induced internalization. EP2 receptors are mainly localized in lung and placental tissues and smooth muscle, contributing to contraction and relaxation mechanisms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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