Thermo Fisher Scientific Prostaglandin E Receptor EP2 Polyclonal Antibody, Biotin
Prostaglandin E Receptor EP2를 인식하는 Biotin-conjugated Rabbit Polyclonal Antibody. WB, IHC, ICC, ELISA 등 다양한 응용 가능. Human 및 Mouse 시료에 반응. Affinity chromatography로 정제된 고순도 항체로 연구용에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| Immunocytochemistry (ICC/IF) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
| Immunomicroscopy (IM) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 300–350 of human Prostaglandin E2 receptor EP3 subtype |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 0.5% BSA, 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Prostaglandins are produced by the metabolism of arachidonic acid. Prostaglandin E2 (PGE2) is one of the five physiologically significant prostanoids. Its wide spectrum of physiologic and pharmacologic effects is mediated through binding to Prostaglandin E2 receptors (EP1, EP2, EP3, and EP4). These receptors influence immune, endocrine, cardiovascular, renal, and reproductive systems, as well as smooth muscle activity.
PGE2 is abundant in the brain, where it plays roles in neural functions and inflammation. EP2 receptors are 358 amino acid G-protein coupled receptors that stimulate adenylyl cyclase via Gs coupling and do not undergo PGE2-induced internalization. EP2 receptors are involved in smooth muscle contraction and relaxation, and are mainly localized in lung and placental tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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