Thermo Fisher Scientific Phospho-p70 S6 Kinase (Thr421) Polyclonal Antibody
Thr421 부위 인산화된 p70 S6 Kinase를 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF에 사용 가능. Jurkat, MCF-7 등 다양한 세포에서 검증됨. 세포 성장, 단백질 합성 관련 연구에 적합.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | - |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:100–1:200 | - |
Product Specifications
| Specification | Description |
|---|---|
| Published species | Mouse |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide sequence around phosphorylation site of threonine 421 (P-R-T(p)-P-V) derived from Human p70 S6 Kinase |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2554341 |
Product Specific Information
A suggested positive control for Western blot is Jurkat cells; for IHC, human breast carcinoma; for ICC/IF, MCF-7 cells.
Target Information
RPS6KB1 (p70S6K) is a serine/threonine kinase with two non-identical catalytic domains that phosphorylates residues of the S6 ribosomal protein. It is mainly localized in the cytoplasm and plays a key role in growth factor-regulated cell proliferation, motility, immune response, and tissue repair. Acting downstream of PI3-kinase, its main physiological target is the S6 ribosomal protein, which mediates protein synthesis upregulation. Overexpression and DNA amplification of p70 S6 kinase are observed in certain breast cancer cell lines.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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