Thermo Fisher Scientific LXR alpha + LXR beta Polyclonal Antibody
LXR alpha 및 LXR beta를 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, WB, IHC, ICC, ELISA 등 다양한 응용에 사용 가능. 인간, 마우스, 랫, 제노푸스 반응성. 고순도 Protein A 정제 및 안정적인 액상 형태로 제공.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat, Xenopus |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human LXR alpha + LXR beta |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
NR1H3 (oxysterols receptor LXR-alpha) is a nuclear receptor that exhibits ligand-dependent transcriptional activation activity. Its interaction with retinoic acid receptor (RXR) shifts RXR from a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES.
LXRES are DR4-type response elements characterized by direct repeats of two similar hexanucleotide half-sites spaced by four nucleotides.
NR1H3 plays an important role in cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR, and LRP8. It also functionally interplays with RORA for the regulation of genes involved in liver metabolism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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