Thermo Fisher Scientific JAM-A Polyclonal Antibody
JAM-A (CD321) 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, IP 등 다양한 응용 가능. 4°C 보관, 액상 형태, 1년 권장 보관 기간. 인간, 마우스, 랫트 반응 예측.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:100–1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 249 and 299 of human Junctional Adhesion Molecule A (JAM-A, CD321, UniProt ID: Q9Y624-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections
- Based on 100% sequence identity, this antibody is predicted to react with Mouse and Rat
Target Information
CD321 (F11R, JAM-1, JAM-A) is a cell-surface adhesion molecule belonging to the Ig superfamily of receptors.
It is a 32–41 kD glycoprotein with two extracellular Ig-like domains, a transmembrane region, and a short cytosolic tail.
The protein assembles at the membrane as a homodimer and interacts with other membrane proteins including integrins.
CD321 is expressed on leukocytes, platelets, erythrocytes, stem cells, epithelial and endothelial cells, and mediates cell-cell contact.
It is associated with epithelial tight junction components such as ZO-1 and occludin and plays roles in maintaining barrier integrity, hematopoiesis, angiogenesis, and tumor progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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