Thermo Fisher Scientific JAM-A Polyclonal Antibody
JAM-A (CD321)에 특이적인 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, IP 등 다양한 응용에 적합합니다. 인간에 반응하며 Mouse, Rat에서도 예측 반응. 항원 친화 크로마토그래피로 정제된 액상 제품으로 4°C에서 보관합니다.
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Thermo Fisher Scientific JAM-A Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:100–1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 249 and 299 of human Junctional Adhesion Molecule A (JAM-A, CD321, UniProt ID: Q9Y624-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections
- Based on 100% sequence identity, this antibody is predicted to react with Mouse and Rat
Target Information
CD321 (F11R, JAM-1, JAM-A) is a cell-surface adhesion molecule belonging to the Ig superfamily of receptors.
It is a 32–41 kD glycoprotein with two extracellular Ig-like domains, a transmembrane region, and a short cytosolic tail.
The protein forms homodimers at the membrane and associates with other membrane proteins including integrins.
CD321 is expressed on leukocytes, platelets, erythrocytes, stem cells, epithelial and endothelial cells, and mediates cell-cell contact.
It is closely associated with epithelial tight junction components such as ZO-1 and occludin, and plays roles in maintaining epithelial/endothelial barriers, hematopoiesis, angiogenesis, and tumor progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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