Thermo Fisher Scientific P4HTM Polyclonal Antibody
Rabbit polyclonal antibody recognizing Human HIF Prolyl Hydroxylase 4. Validated for WB and IHC(P). High purity via antigen affinity chromatography. Supplied as liquid, 1 mg/mL in PBS with BSA and glycerol. For research use only.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 99–382 of Human HIF Prolyl Hydroxylase 4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 1% BSA, 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4 °C (short term). For long-term storage, keep at −20 °C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2548226 |
Product Specific Information
- Recommended positive controls: A549, H1299, HCT116
- Predicted reactivity: Mouse (94%), Bovine (92%)
- Store as a concentrated solution. Centrifuge briefly before opening the vial.
Target Information
Prolyl hydroxylase 4 is an enzyme that modifies HIF‑alpha. Classic prolyl hydroxylases are found in the endoplasmic reticulum and modify collagen, whereas HIF is an intracellular protein with distinct hydroxylation sites.
HIF is a transcriptional complex critical for oxygen homeostasis. Prolyl hydroxylase is essential for cellular oxygen sensing.
Under normoxic conditions, prolyl hydroxylases hydroxylate specific prolyl residues in HIF‑alpha, leading to its degradation. Under hypoxia, hydroxylation is reduced, stabilizing HIF and promoting angiogenesis.
Prolyl hydroxylase 4 catalyzes the post‑translational formation of 4‑hydroxyproline in HIF‑alpha proteins and may function as a cellular oxygen sensor, targeting HIF for proteasomal degradation via the von Hippel–Lindau ubiquitylation complex.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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