Thermo Fisher Scientific Phospho-ACK1 (Tyr859, Tyr860) Polyclonal Antibody
ACK1 단백질의 Tyr859/Tyr860 인산화 형태를 특이적으로 검출하는 Rabbit Polyclonal 항체. Western blot 및 Immunocytochemistry에 적합. Human 시료 반응성. 고순도 정제 및 안정적 액상 형태로 제공. 연구용 전용 제품.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TNK2 (Accession Q07912), corresponding to amino acid residues around phosphorylated Tyr859 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2815878 |
Product Specific Information
This antibody detects endogenous levels of ACK1 only when phosphorylated at Tyr859/Tyr860, which site was historically referenced as Tyr857/Tyr859.
Target Information
TNK2 (ACK, activated Cdc42-associated kinase) is a non-receptor tyrosine kinase that signals downstream of Cdc42. TNK2 is known to be involved in tumorigenesis and metastasis, particularly in prostate cancer. It mediates CDC42-dependent cell migration via phosphorylation of BCAR1 and may play roles in synaptic function, plasticity, and brain development. TNK2 activates AKT1 by phosphorylating Tyr-176, and phosphorylates AR on Tyr-267 and Tyr-363 to promote androgen-responsive enhancer recruitment. It also phosphorylates WWOX (Tyr-287), MCF2, and WASP, contributing to control of AXL receptor levels and conferring metastatic properties on cancer cells through regulation of tumor suppressors and pro-survival factors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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