Thermo Fisher Scientific Mouse NOXA Synthetic Peptide
마우스 Noxa 단백질의 N-말단 17개 아미노산 서열에 해당하는 합성 펩타이드입니다. 항체 PA5-19977의 블로킹 펩타이드로 사용 가능합니다. 세포사멸 연구 및 p53 관련 경로 분석에 유용합니다. 연구용으로만 사용됩니다.
- 판매단위
- pk
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
Product Specific Information
This peptide corresponds to 17 amino acids near the amino terminus of mouse Noxa.
PEP-0305 can be used as a blocking peptide with polyclonal antibody PA5-19977.
Target Information
Apoptosis is related to many diseases and developmental processes. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes including p53R2, p53AIP1, and PUMA.
A new p53 target gene, Noxa, was identified, encoding a protein belonging to the subfamily of BH3-only proapoptotic proteins. Noxa and PUMA are both transcriptional targets of p53.
X-ray irradiation increases p53-dependent Noxa mRNA and protein levels. When ectopically expressed, Noxa interacts with anti-apoptotic Bcl-2 family members, resulting in caspase-9 activation.
Noxa, like PUMA, localizes to mitochondria and induces apoptosis in response to p53, representing a direct mediator of p53-induced apoptosis. Increased levels of p53 and its target gene Noxa are associated with impaired tumor development.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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