Thermo Fisher Scientific Mouse NOXA Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 17 amino acids near the amino terminus of mouse Noxa.
PEP-0305 can be used as a blocking peptide with polyclonal antibody PA5-19977.

Target Information

Apoptosis is related to many diseases and developmental processes. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes including p53R2, p53AIP1, and PUMA.
A new p53 target gene, Noxa, was identified, encoding a protein belonging to the subfamily of BH3-only proapoptotic proteins. Noxa and PUMA are both transcriptional targets of p53.
X-ray irradiation increases p53-dependent Noxa mRNA and protein levels. When ectopically expressed, Noxa interacts with anti-apoptotic Bcl-2 family members, resulting in caspase-9 activation.
Noxa, like PUMA, localizes to mitochondria and induces apoptosis in response to p53, representing a direct mediator of p53-induced apoptosis. Increased levels of p53 and its target gene Noxa are associated with impaired tumor development.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.