ELK Biotechnology c-Abl (phospho-Thr735) rabbit pAb
c-Abl (phospho-Thr735) rabbit pAb는 인산화된 c-Abl 단백질(Thr735)을 인식하는 폴리클로날 항체로, WB 분석에 적합합니다. 세포 내 신호전달 및 스트레스 반응 연구에 활용되며, 사람, 쥐, 랫트 시료에서 반응성을 보입니다. -20°C에서 1년 보관 가능합니다.
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제품명
c-Abl (phospho-Thr735) rabbit pAb
대체 명칭
Tyrosine-protein kinase ABL1 (EC 2.7.10.2), Abelson murine leukemia viral oncogene homolog 1, Abelson tyrosine-protein kinase 1, Proto-oncogene c-Abl, p150
제품 정보
| 항목 | 내용 |
|---|---|
| Applications | WB |
| Recommended Dilutions | WB 1:1000–2000 |
| Immunogen | Synthesized phospho peptide around human c-Abl (Thr735) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 140 kDa (200 kDa BCR-ABL complex) |
| Gene ID (Human) | 25 |
| Human Swiss-Prot No. | P00519 |
| Species Reactivity | Human, Rat, Mouse |
| Cellular Localization | Cytoplasm, cytoskeleton, nucleus, mitochondrion. Shuttles between nucleus and cytoplasm depending on environmental signals. Sequestered into cytoplasm via interaction with 14-3-3 proteins. Localizes to mitochondria in response to oxidative stress. Isoform IB: nucleus membrane, lipid-anchor; the myristoylated c-ABL protein is reported to be nuclear. |
배경 (Background)
This gene is a proto-oncogene encoding a protein tyrosine kinase involved in various cellular processes including cell division, adhesion, differentiation, and stress response. The activity of the protein is negatively regulated by its SH3 domain, and deletion of this region results in oncogenic transformation. The ubiquitously expressed protein has DNA-binding activity regulated by CDC2-mediated phosphorylation, suggesting a role in the cell cycle. This gene is known to fuse with various translocation partner genes in leukemias, most notably the t(9;22) translocation forming the BCR-ABL fusion. Alternative splicing produces two transcript variants with different first exons spliced to common downstream exons.
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