ELK Biotechnology c-Abl (phospho-Tyr412) rabbit pAb
c-Abl (phospho-Tyr412) rabbit pAb는 인산화된 c-Abl 단백질을 검출하기 위한 고특이성 폴리클로날 항체입니다. WB에 적합하며, 인간·쥐·마우스 시료에서 반응합니다. 세포 내 신호전달 및 종양 연구에 유용합니다.
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제품명
c-Abl (phospho-Tyr412) rabbit pAb
공급업체
ELK Biotechnology
제품 설명
본 항체는 인산화된 Tyr412 부위를 포함하는 인간 c-Abl 단백질을 인식하도록 설계된 폴리클로날 항체입니다. 세포 내 신호전달, 세포 분열, 스트레스 반응 및 암 관련 연구에 활용됩니다.
제품 스펙
| 항목 | 내용 |
|---|---|
| Alternative Names | Tyrosine-protein kinase ABL1 (EC 2.7.10.2), Abelson murine leukemia viral oncogene homolog 1, Abelson tyrosine-protein kinase 1, Proto-oncogene c-Abl, p150 |
| Applications | WB |
| Recommended Dilutions | WB 1:1000–2000 |
| Immunogen | Synthesized phospho peptide around human c-Abl (Tyr412) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 140 (200 kDa BCR-ABL complex) |
| GeneID (Human) | 25 |
| Human Swiss-Prot No | P00519 |
| Cellular Localization | Cytoplasm, cytoskeleton, nucleus, mitochondrion. Shuttles between nucleus and cytoplasm depending on environmental signals. Sequestered into cytoplasm via 14-3-3 protein interaction. Localizes to mitochondria under oxidative stress. Isoform IB: nuclear membrane, lipid-anchor; myristoylated c-Abl reported to be nuclear. |
| Species Reactivity | Human, Rat, Mouse |
Background
This gene is a proto-oncogene encoding a protein tyrosine kinase involved in various cellular processes such as cell division, adhesion, differentiation, and stress response. Its activity is negatively regulated by the SH3 domain; deletion of this region results in oncogenic transformation. The protein exhibits DNA-binding activity regulated by CDC2-mediated phosphorylation, indicating a role in the cell cycle. The gene is known to fuse with multiple translocation partner genes in leukemias, notably the t(9;22) translocation producing the BCR-ABL fusion. Alternative splicing produces two transcript variants with distinct first exons spliced to common exons.
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