ELK Biotechnology c-Abl (phospho-Tyr89) rabbit pAb
c-Abl (phospho-Tyr89) rabbit polyclonal antibody로, 인산화된 Tyr89 부위를 특이적으로 인식합니다. Western blot에 적합하며, 사람, 쥐, 생쥐 시료에서 반응합니다. 세포 내 신호전달 및 암 관련 연구에 유용합니다.
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제품명
c-Abl (phospho-Tyr89) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | c-Abl (phospho-Tyr89) rabbit pAb |
| Alternative Names | Tyrosine-protein kinase ABL1 (EC 2.7.10.2), Abelson murine leukemia viral oncogene homolog 1, Abelson tyrosine-protein kinase 1, Proto-oncogene c-Abl, p150 |
| Applications | WB |
| Recommended Dilutions | WB 1:1000–2000 |
| Immunogen | Synthesized phospho peptide around human c-Abl (Tyr89) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 140 kDa (200 kDa BCR-ABL complex) |
| GeneID (Human) | 25 |
| Human Swiss-Prot No | P00519 |
| Cellular Localization | Cytoplasm, cytoskeleton, nucleus, mitochondrion. Shuttles between nucleus and cytoplasm depending on environmental signals. Sequestered into cytoplasm via interaction with 14-3-3 proteins. Localizes to mitochondria in response to oxidative stress. Isoform IB: nucleus membrane, lipid-anchor. Myristoylated c-ABL protein is reported to be nuclear. |
| Species Reactivity | Human, Rat, Mouse |
Background
This gene is a proto-oncogene that encodes a protein tyrosine kinase involved in cellular processes such as cell division, adhesion, differentiation, and stress response. The protein’s activity is negatively regulated by its SH3 domain; deletion of this region results in oncogenic transformation. It possesses DNA-binding activity regulated by CDC2-mediated phosphorylation, suggesting a role in the cell cycle. The gene is known to form fusions with various translocation partners in leukemias, most notably the t(9;22) translocation producing the BCR-ABL fusion. Alternative splicing yields two transcript variants with alternative first exons joined to common exons.
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