ELK Biotechnology CaMK2 (Phospho-Thr286) Antibody
CaMK2 (Phospho-Thr286) 인산화 특이적 항체로 WB 및 ELISA에 적합. 인간, 마우스, 랫트 반응성. 폴리클로날 IgG 형식으로 1 mg/ml 농도 제공. -20°C 보관 시 1년 안정적.
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CaMK2 (Phospho-Thr286) Antibody
제품 정보
| 항목 | 내용 |
|---|---|
| Product Name | CaMK2 (Phospho-Thr286) Antibody |
| Alternative Names | Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta; CaMK-II subunit delta; EC 2.7.11.17) |
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:500–2000, ELISA (peptide) 1:5000–20000 |
| Immunogen | Synthesized phospho peptide derived from human CaMK2 (Phospho-Thr286) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 54 kD |
| Gene ID (Human) | 817 |
| Human Swiss-Prot No. | Q9UQM7 / Q13557 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Cell junction, synapse; postsynaptic density; dendritic spine; dendrite; postsynaptic lipid rafts |
Background
The product of this gene belongs to the serine/threonine protein kinases family and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2008]
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