ELK Biotechnology CASC3 rabbit pAb
CASC3 단백질을 인식하는 rabbit polyclonal antibody로, WB 실험에 적합합니다. 인간, 생쥐, 랫트에 반응하며, 세포질 및 핵 내에서 발현되는 CASC3 단백질 검출에 유용합니다. 고순도 IgG 형식으로 안정적 보관 가능합니다.
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제품명
CASC3 rabbit pAb
제품 개요
CASC3 단백질을 표적하는 rabbit polyclonal antibody입니다. 인간, 생쥐, 랫트 시료에서 Western blot(WB) 분석에 사용됩니다.
제품 스펙
| 항목 | 내용 |
|---|---|
| Applications | WB |
| Recommended Dilutions | WB 1:500–2000 |
| Immunogen | Synthesized peptide derived from human CASC3 (AA range: 434–484) |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| GeneID (Human) | 22794 |
| Human Swiss-Prot No | O15234 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치
Cytoplasm, perinuclear region, nucleus, nucleus speckle, cytoplasmic stress granule, cytoplasmic ribonucleoprotein granule, cell projection (dendrite).
Shuttles between the nucleus and cytoplasm in an XPO1/CRM1-dependent manner. Transported to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA (PubMed:15166247).
In nuclear speckles, colocalizes with MAGOH. Under stress conditions, colocalizes with FMR1 and TIA1, but not MAGOH and RBM8A EJC core factors, in cytoplasmic stress granules (PubMed:17652158).
In dendrites of hippocampal neurons, localizes to dendritic ribonucleoprotein granules (By similarity).
배경 정보
The product of this gene is a core component of the exon junction complex (EJC), a protein complex deposited on spliced mRNAs at exon-exon junctions and involved in nonsense-mediated mRNA decay (NMD).
The encoded protein binds RNA and interacts with other EJC core components. It predominantly localizes in the cytoplasm but shuttles into the nucleus, where it is found in nuclear speckles.
[provided by RefSeq, Jul 2008]
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