ELK Biotechnology Caspase-8 rabbit pAb

Caspase-8 rabbit pAb

제품 개요

Caspase-8은 세포자멸사(apoptosis)의 실행 단계에서 핵심적인 역할을 하는 시스테인-아스파르트산 프로테아제 계열의 효소입니다. 본 항체는 인간 Caspase-8 유래 합성 펩타이드로부터 제작된 토끼 폴리클로날 항체로, 다양한 종에서 Caspase-8 단백질 검출에 사용됩니다.

제품 정보

Background

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of large and small subunits. Caspase-8 is involved in programmed cell death induced by Fas and various apoptotic stimuli. Its N-terminal FADD-like death effector domain suggests interaction with Fas-interacting protein FADD. Caspase-8 has been detected in the insoluble fraction of affected brain regions from Huntington disease patients, implicating its role in neurodegenerative diseases.