ELK Biotechnology CASQ1 rabbit pAb
CASQ1 rabbit pAb는 인간, 마우스, 랫트에 반응하는 다클론 항체로, WB 분석에 적합합니다. 인간 CASQ1 유래 합성 펩타이드를 면역원으로 사용하며, 근육 내 칼슘 조절 연구에 활용됩니다. -20°C에서 1년간 안정적으로 보관 가능합니다.
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제품명
CASQ1 rabbit pAb
적용 분야
- Western Blot (WB)
권장 희석 배율
- WB: 1:500–2000
제품 정보
| 항목 | 내용 |
|---|---|
| Immunogen | Synthesized peptide derived from human CASQ1 (AA range: 322–372) |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| GeneID (Human) | 844 |
| Human Swiss-Prot No | P31415 |
| Species Reactivity | Human, Mouse, Rat |
| Storage | -20°C / 1 year |
| Host | Rabbit |
세포 내 위치
Endoplasmic reticulum, Sarcoplasmic reticulum, Sarcoplasmic reticulum lumen, Sarcoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side; Mitochondrion matrix.
This isoform of calsequestrin occurs in the sarcoplasmic reticulum’s terminal cisternae luminal spaces of fast skeletal muscle cells. Preferentially forms linear and round aggregates in the endoplasmic reticulum (ER) of resting cells (PubMed:28895244).
In a minority of cells, homogeneously detected in the ER lumen (PubMed:28895244).
Colocalizes with STIM1 at endoplasmic reticulum in response to a depletion of intracellular calcium (PubMed:27185316).
배경 정보
This gene encodes the skeletal muscle-specific member of the calsequestrin protein family.
Calsequestrin functions as a luminal sarcoplasmic reticulum calcium sensor in both cardiac and skeletal muscle cells.
Also known as calmitine, it acts as a calcium regulator in the mitochondria of skeletal muscle.
This protein is absent in patients with Duchenne and Becker types of muscular dystrophy.
[Provided by RefSeq, Jun 2013]
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