Thermo Fisher Scientific TFAR19/PDCD5 Polyclonal Antibody
TFAR19/PDCD5 단백질을 인식하는 Rabbit Polyclonal 항체로, Western Blot, IHC, ICC, ELISA 등 다양한 응용에 사용 가능. Human, Mouse, Rat 반응성. Protein A 정제, 1 mg/mL 농도, -20°C 보관. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200–1:400 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human TFAR19 (amino acids 45–125) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Programmed cell death 5 (PDCD5) is a human apoptosis-related protein that plays an early and universal role in apoptosis. It is widely expressed and upregulated in cells undergoing apoptosis, rapidly translocating from the cytoplasm to the nucleus. PDCD5 has a compact core structure with two mobile N-terminal alpha-helices and a flexible unstructured C-terminal region. Charged residues are crucial for its apoptosis-promoting and translocation functions. PDCD5 can enhance TAJ/TROY-induced paraptosis-like cell death and acts as a Tip60 co-activator to promote apoptosis. Variations in the PDCD5 promoter region may influence susceptibility to chronic myelogenous leukemia and lung cancer, suggesting a role as a tumor suppressor gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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