ELK Biotechnology CRBB3 rabbit pAb

ELK Biotechnology CRBB3 rabbit pAb

제품 개요

CRBB3 단백질을 인식하는 토끼 폴리클로날 항체로, Western blot(WB) 실험에 적합합니다. 인간, 마우스, 랫트 시료에서 반응성을 보입니다.

제품 정보

Background

Crystallins are separated into two classes: taxon-specific (enzyme) and ubiquitous. The ubiquitous class constitutes the major proteins of vertebrate eye lens and maintains lens transparency and refractive index. Lens central fiber cells lose their nuclei during development, so crystallins are synthesized and retained throughout life, making them extremely stable. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins form a superfamily. Alpha and beta families are further divided into acidic and basic groups. Beta-crystallins, the most heterogeneous, differ by the presence of a C-terminal extension (present in the basic group, absent in the acidic group). Beta-crystallins form aggregates of varying sizes and can self-associate to form dimers or heterodimers. This gene, a beta basic group member, is part of a cluster with beta-A4, beta-B1, and beta-B2. Mutations in this gene result in congenital nuclear autosomal recessive cataract type 2. (provided by RefSeq, Feb 2013)