ELK Biotechnology DAZ4 rabbit pAb
DAZ4 단백질을 인식하는 토끼 폴리클로날 항체로, WB에 적합합니다. 사람, 쥐, 랫트 시료에 반응하며 세포질과 핵에 주로 존재하는 단백질을 검출할 수 있습니다. 정자 형성과 관련된 연구에 유용합니다.
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제품명
DAZ4 rabbit pAb
제품 설명
DAZ4 단백질을 인식하는 토끼 폴리클로날 항체입니다. 주로 Western blot(WB)에 사용되며, 사람, 랫트, 마우스 시료에서 반응합니다. 세포질 및 핵에 위치하는 단백질을 검출할 수 있습니다.
제품 사양
| 항목 | 내용 |
|---|---|
| Product name | DAZ4 rabbit pAb |
| Applications | WB |
| Recommended Dilutions | WB 1:500–2000 |
| Immunogen | Synthesized peptide derived from human DAZ4 (AA range: 525–575) |
| Host Species | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Gene ID (Human) | 57135 |
| Human Swiss-Prot No. | Q86SG3 |
| Species Reactivity | Human, Rat, Mouse |
| Cellular Localization | Cytoplasm, Nucleus. Predominantly cytoplasmic. Nuclear at some stages of spermatozoid development. Localizes to both nuclei and cytoplasm during spermatozoid differentiation. Nuclear in fetal gonocytes and spermatogonial nuclei, then relocates to cytoplasm during male meiosis. |
Background
This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene also contains a 10.8 kb region that may be amplified; this region includes five exons that encode an RNA recognition motif (RRM) domain. This gene contains two copies of the 10.8 kb repeat. Alternatively spliced transcript variants encoding different isoforms have been described. (RefSeq, Feb 2011)
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