ELK Biotechnology GIT2 (phospho-Tyr592) rabbit pAb
GIT2 단백질의 Tyr592 인산화 형태를 인식하는 rabbit polyclonal 항체로, WB에 적합하며 1:1000~2000 희석 비율로 사용 가능. 세포 이동 및 세포골격 조절 연구에 유용. Human, Rat, Mouse에 반응.
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제품명
GIT2 (phospho-Tyr592) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | ARF GTPase-activating protein GIT2 (ARF GAP GIT2), Cool-interacting tyrosine-phosphorylated protein 2 (CAT-2, CAT2), G protein-coupled receptor kinase-interactor 2 (GRK-interacting protein 2) |
| Applications | WB |
| Recommended Dilutions | WB 1:1000–2000 |
| Immunogen | Synthesized phospho peptide around human GIT2 (Tyr592) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 84 kDa |
| Gene ID (Human) | 9815 |
| Human Swiss-Prot No. | Q14161 |
| Cellular Localization | Nucleoplasm, focal adhesion |
| Species Reactivity | Human, Rat, Mouse |
Background
This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity.
GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins.
GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility.
This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences with respect to ARF GAP activity.
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