ELK Biotechnology Doublecortin (Phospho-Ser378) rabbit pAb
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| Product name: | Doublecortin (Phospho-Ser378) rabbit pAb |
| Alternative Names: | Neuronal migration protein doublecortin (Doublin;Lissencephalin-X;Lis-X) |
| Applications: | IHC;IF;WB |
| Recommended Dilutions: | IHC-p 1:50-200, WB 1:500-2000 |
| Immunogen: | Synthesized peptide derived from human Doublecortin (Phospho-Ser378) |
| Storage: | Rabbit |
| Storage: | -20°C/1 year |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Concentration: | 1 mg/ml |
| Observed Band: | 44kD |
| GeneID（Human）: | 1641 |
| Human Swiss-Prot No: | O43602 |
| Cellular localization: | Cytoplasm . Cell projection, neuron projection . Localizes at neurite tips. . |
| Background: | This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia (double cortex syndrome) in females and lissencephaly (`smooth brain&quo |
| Species Reactivity: | Human; Mouse; Rat |
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