ELK Biotechnology Doublecortin (Phospho-Ser378) rabbit pAb

제품명

Doublecortin (Phospho-Ser378) rabbit pAb

공급업체

ELK Biotechnology

제품 개요

Doublecortin (Phospho-Ser378)은 신경세포 이동에 관여하는 단백질로, 미세소관 결합 도메인을 포함하며 뉴런의 발달 및 이동 과정에서 중요한 역할을 합니다. 본 항체는 인산화된 Ser378 부위를 인식하는 rabbit polyclonal antibody입니다.

제품 스펙

Background

This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains that bind microtubules. In the developing cortex, cortical neurons migrate over long distances to reach their final differentiation sites. The encoded protein directs neuronal migration by regulating microtubule organization and stability. It interacts with LIS1, the regulatory gamma subunit of platelet-activating factor acetylhydrolase, which is crucial for proper microtubule function in the developing cortex. Mutations in this gene cause abnormal neuronal migration and cortical layering defects, leading to epilepsy, mental retardation, and subcortical band heterotopia (“double cortex” syndrome) in females and lissencephaly (“smooth brain”) in males.