Thermo Fisher Scientific ATP2C1 Polyclonal Antibody
ATP2C1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 인간, 마우스, 랫트 반응성. WB, IHC, ELISA에 적합. 고순도 Affinity Chromatography 정제, -20°C 보관. 연구용 전용.
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Thermo Fisher Scientific ATP2C1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:100–1:500 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| ELISA | 1 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 400–660 of human ATP2C1 (NP_001186114.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.47 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2854841 |
Product Specific Information
Immunogen sequence:
AVSRIVEAGC VCNDAVIRNN TLMGKPTEGA LIALAMKMGL DGLQQDYIRK AEYPFSSEQK WMAVKCVHRT QQDRPEICFM KGAYEQVIKY CTTYQSKGQT LTLTQQQRDV YQQEKARMGS AGLRVLALAS GPELGQLTFL GLVGIIDPPR TGVKEAVTTL IASGVSIKMI TGDSQETAVA IASRLGLYSK TSQSVSGEEI DAMDVQQLSQ IVPKVAVFYR ASPRHKMKII KSLQKNGSVV AMTGDGVNDA VALKAADIGV A
Target Information
ATP2C1, also known as secretory pathway Ca²⁺/Mn²⁺-ATPase (SPCA1), belongs to the family of P-type cation transport ATPases.
This magnesium-dependent enzyme catalyzes ATP hydrolysis coupled with calcium transport from the cytosol to the Golgi lumen.
Defects in ATP2C1 cause Hailey-Hailey disease, characterized by persistent skin blisters and erosions.
Unlike ATP2C2, ATP2C1 is ubiquitously expressed, shows a lower turnover rate for Ca²⁺-ATPase reaction, and higher affinity for cytosolic Ca²⁺ activation.
Recent studies suggest ATP2C1 regulates IGF1R processing in tumor progression of basal breast cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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