Thermo Fisher Scientific RUVBL2 Monoclonal Antibody (OTI1A6), TrueMAB

Applications 및 Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step.
Recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).

Target Information

RUVBL2 possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5′→3′) activity.
It is a component of the NuA4 histone acetyltransferase complex involved in transcriptional activation via acetylation of nucleosomal histones H4 and H2A.
This modification affects nucleosome–DNA interactions and facilitates recruitment of transcriptional regulators.
NuA4 is implicated in oncogene-mediated growth induction, tumor suppressor-mediated arrest, replicative senescence, apoptosis, and DNA repair.
RUVBL2, in association with RUVBL1 and EP400, contributes to the ATPase and helicase activities of NuA4.
It plays a role in MYC-driven oncogenic transformation and modulates LEF1/TCF1–CTNNB1 complex transcriptional activation, while potentially inhibiting ATF2 transcriptional activity.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.