Thermo Fisher Scientific CD123 Polyclonal Antibody
CD123(IL3RA) 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot, IHC(P), ELISA에 적합하며 인간, 마우스, 랫트에 반응. 고순도 친화 크로마토그래피 정제, PBS/glycerol 완충액에 보관. 연구용 전용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 1–100 of human IL3RA (NP_002174.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.47 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2806378 |
Product Specific Information
- Immunogen sequence:
MVLLWLTLLL IALPCLLQTK EDPNPPITNL RMKAKAQQLT WDLNRNVTDI ECVKDADYSM PAVNNSYCQF GAISLCEVTN YTVRVANPPF STWILFPENS - Positive Samples: A-549
- Cellular Location: Membrane, Single-pass type I membrane protein
Target Information
IL-3Ra (Interleukin-3 receptor subunit alpha) belongs to the type I cytokine receptor family and forms a heterodimer with a unique alpha chain paired with the common beta (βc or CDw131) subunit.
IL-3Ra transmits the signal of Interleukin-3, and IL-3Ra/IL-3Rb heterodimerization is induced by Interleukin-3, which is required for receptor activation but not high-affinity binding.
IL-3Ra subunits are reported to be overexpressed on acute myeloid leukemia (AML) blasts compared with normal hematopoietic cells, making them potential targets for novel therapeutic agents.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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