Thermo Fisher Scientific SCAMP5 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1.0 µg/mL

Product Specifications

Product Specific Information

• Immunogen sequence: VFSFIALSMV HKFYRGSGGS FSKAQEEWTT GAWKNPHVQQ AAQNAAMGAA
• For short term use, store at 2–8°C up to 1 week.
• For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Predicted homology: Cow 100%, Dog 100%, Guinea Pig 100%, Horse 100%, Human 100%, Mouse 100%, Rabbit 100%, Rat 100%, Zebrafish 93%

Target Information

Secretory carrier membrane proteins (SCAMPs) are components of post-Golgi membranes and are implicated in membrane trafficking.
In fibroblasts, SCAMPs are concentrated in compartments involved in receptor recycling and endocytosis.
In neurons, SCAMPs are associated with synaptic vesicles, secretion granules, and transporter vesicles.

SCAMPs are composed of four central transmembrane regions and a cytoplasmic tail.
Of the five known SCAMPs:

• SCAMPs 1–3 contain N-terminal NPF repeats interacting with EH domain proteins involved in vesicle budding.
• SCAMPs 4 and 5 lack the N-terminal NPF repeats.
• SCAMPs 1–4 are ubiquitously coexpressed, while SCAMP5 is detectable only in the brain and expressed late in development, coinciding with mature synapse expansion.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.