Thermo Fisher Scientific SNAP23 Polyclonal Antibody
SNAP23 단백질을 인식하는 Thermo Fisher Scientific의 염소 유래 polyclonal 항체. Western blot 및 IHC(P)에서 검증됨. 인간에 반응하며, 마우스·랫·소에서도 예측 반응. 액상 형태로 제공되며, -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–0.3 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 3.75 µg/mL |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (QIKRITDKAD) corresponding to the internal amino acids of SNAP23 (aa 183–193) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10980955 |
Product Specific Information
- This antibody is predicted to react with bovine, mouse, and rat based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 8,000.
Target Information
Specificity of vesicular transport is regulated by the interaction of vesicle-associated membrane proteins (synaptobrevin/VAMP) with target compartment membrane proteins (syntaxin). These, together with SNAP25, form a complex that acts as a binding site for the general membrane fusion machinery.
Synaptobrevin/VAMP and syntaxin are involved in vesicular transport across most cells, while SNAP25 is mainly expressed in the brain. SNAP23, a homolog of SNAP25, is ubiquitously expressed and facilitates vesicle/target membrane fusion in non-neuronal tissues. It binds tightly to multiple syntaxins and synaptobrevins/VAMPs and is an essential component of the high-affinity receptor for the membrane fusion machinery, regulating vesicle docking and fusion. Two alternative transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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