Thermo Fisher Scientific PON3 Polyclonal Antibody
Thermo Fisher Scientific의 PON3 폴리클로날 항체는 인간 PON3 단백질을 인식하며, Western blot과 ELISA에 적합합니다. Rabbit IgG로 제작되었고, 액상 형태로 제공됩니다. 고순도 친화 크로마토그래피 정제, 안정적인 PBS/glycerol 버퍼 구성으로 연구용에 최적화되어 있습니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
ELISA
- Tested Concentration: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 250–350 of human PON3 (NP_0009311) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.07 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2901312 |
Product Specific Information
- Positive Samples: Jurkat, HepG2
- Immunogen sequence:
HDNWDLTQLK VIQLGTLVDN LTVDPATGDI LAGCHPNPMK LLNYNPEDPP GSEVLRIQNV LSEKPRVSTV YANNGSVLQG TSVASVYHGK ILIGTVFHKT L
Target Information
Paraoxonase-1 (PON1) is a calcium-dependent ester hydrolase associated with apoA-I in HDL and prevents LDL oxidation. Polymorphisms in the human PON1 gene correlate with coronary artery disease. PON1 activity is reduced in individuals prone to atherosclerosis such as those with diabetes, familial hypercholesterolemia, and renal disease.
PON2 is an intracellular protein protecting against oxidative damage. PON3, similar to PON1, differs in substrate specificity and is implicated in reducing coronary artery disease risk. Human PON3 shares three conserved cysteine residues with PON1, essential for its in vivo activity. PON1-based catalytic scavengers may offer protection against organophosphate intoxication.
⚠ WARNING: This product can expose you to chemicals including mercury, known to cause birth defects or reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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