Thermo Fisher Scientific ICAM-1 Monoclonal Antibody (W-CAM-1)

Applications

Tested Dilution

Publications

Immunohistochemistry (IHC)

Assay-dependent

View 2 publications 2 publications

Immunocytochemistry (ICC/IF)

-

View 1 publication 1 publication

Flow Cytometry (Flow)

Assay-dependent

-

Neutralization (Neu)

Assay-dependent

View 1 publication 1 publication

Product Specifications

Published species

Human, Rat

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

W-CAM-1

Immunogen

Raji Burkitt lymphoma cells if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:ICAM-1 (CD54),uniProtId:P05362-1,ncbiNodeId:9606,antigenRange:1-532,antigenLength:532,antigenImageFileName:MS305PABX_ICAM-1_CD54_P05362-1_House_mouse.svg,antigenImageFileNamePDP:MS305PABX_ICAM-1_CD54_P05362-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Storage conditions

-20°C

Shipping conditions

Dry ice

RRID

AB_417070

Product Specific Information

MS305PABX targets CD54 in FACS, IF, IHC, and Neu applications and shows reactivity with Human samples.

The MS305PABX immunogen is raji Burkitt lymphoma cells.

MS305PABX detects CD54 which has a predicted molecular weight of approximately 55 kDa.

Target Information

ICAM-1 (CD54) is an 85-110 kDa single-chain type 1 integral membrane glycoprotein with an extracellular domain of five immunoglobulin superfamily repeats, a transmembrane region and a cytoplasmic domain. ICAM-1 has 7 potential N-linked glycosylation sites and shares considerable amino acid sequence homology with ICAM-3 (CD50) and ICAM-2 (CD102). ICAM-1 binds to integrins of type CD11a/CD18 (leukocyte adhesion molecule, LFA-1), or CD11b/CD18 (Mac-1) and is exploited by Rhinovirus as a receptor. ICAM-1 is expressed by activated endothelial cells and detected on epithelial cells, fibroblasts, chondrocytes, B lymphocytes, T lymphocytes (low), monocytes, macrophages, dendritic cells and neutrophils, with lower levels that increase upon inflammation. ICAM-1 is also detected in some carcinoma and melanoma cells. Soluble ICAM-1 is detectable in the plasma and is elevated in patients with various inflammatory syndromes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.