Thermo Fisher Scientific IL-12/IL-23 p40 Monoclonal Antibody (320244), PE

Applications

Tested Dilution

Publications

Flow Cytometry (Flow)

10 µL per million cells

-

Product Specifications

Species Reactivity

Mouse

Host/Isotype

Rat / IgG2a

Class

Monoclonal

Type

Antibody

Clone

320244

Immunogen

E. coli-derived recombinant mouse IL-23 p19 and recombinant mouse IL-12/IL-23 p40 Leu20-Ala196 (Il-23 p19) and Met23-Ser335 (IL-12/IL-23 p40) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:IL-12/IL-23 p40,uniProtId:Q9EQ14-1,ncbiNodeId:10090,antigenRange:20-196,antigenLength:196,antigenImageFileName:MA5-23617_IL-12IL-23_p40_Q9EQ14-1_Rat.svg,antigenImageFileNamePDP:MA5-23617_IL-12IL-23_p40_Q9EQ14-1_Rat_PDP.jpeg,sortOrder:1},{targetFamily:IL-12/IL-23 p40,uniProtId:P43432-1,ncbiNodeId:10090,antigenRange:23-335,antigenLength:335,antigenImageFileName:MA5-23617_IL-12IL-23_p40_P43432-1_Rat.svg,antigenImageFileNamePDP:MA5-23617_IL-12IL-23_p40_P43432-1_Rat_PDP.jpeg,sortOrder:4}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

PE PE PE

Excitation/Emission Max

565/576 nm View spectra

Form

Liquid

Purification

Protein A/G

Storage buffer

Buffered saline solution with BSA

Contains

0.09% sodium azide

Storage conditions

4° C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2605571

Target Information

IL-12 is an interleukin produced by dendritic cells, neutrophils, macrophages and human lymphoblastoid cells as a result of antigenic stimulation. IL-12 is a heterodimeric cytokine encoded by IL-12A (p35) and IL-12B (p40). IL-23 is a heterodimeric cytokine that shares a subunit with IL-12 (IL-12B) along with an IL-23A (IL-23p19) subunit. Functionally, IL-12 increases the expression of vascular endothelial adhesion molecule-1 on the endothelium, directs leukocytes towards tumors and facilitates the ischemic-hemorrhagic necrosis of the tumor tissue. In comparison, IL-23 plays an important role in stimulating memory T-cells, and is required for the induction, expansion, maintenance and downstream effector functions of Th17 cells, which play a vital role in upregulating neutrophil chemokines and various pro-inflammatory cytokines.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.