Thermo Fisher Scientific GEN1 Polyclonal Antibody
Thermo Fisher Scientific GEN1 Polyclonal Antibody는 인간 GEN1 단백질에 특이적인 토끼 IgG 항체로, Western blot 및 ICC/IF에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS 버퍼와 글리세롤로 안정화되어 연구용 DNA 복구 관련 단백질 분석에 활용됩니다.
- 카탈로그번호
- PA554137
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 0.04–0.4 µg/mL
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human GEN1. Recombinant protein control fragment (Product #RP-92437) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2641957 |
Product Specific Information
Immunogen sequence:
SILSVKESCI ANSGSDCTSH LSKDLPGIPL QNESRDSKIL KGDQLLQEDY KVNTSVPYSV SNTVVKTCNV RPPNTALDHS RKVDMQTTRK ILMKKSVCLD RHSSDEQSAP VFGKAKYTTQ RMKHSSQKHN SSHFKESGHN KLSSPKI
Highest antigen sequence identity to the following orthologs:
- Mouse: 50%
- Rat: 47%
Target Information
Xeroderma pigmentosum type G (XPG) is a human genetic disease exhibiting extreme sensitivity to sunlight. The XPG protein, a member of the flap endonuclease 1 (FEN-1) structure-specific DNA repair endonuclease family, is essential for DNA repair of solar UV-induced damages.
Human XPG nuclease makes the 3′ incision during nucleotide excision repair of DNA and cleaves model DNA bubble structures near the junction of unpaired DNA with duplex regions.
A 29-amino acid region of human XPG (residues 981–1009) contains PCNA binding activity, with Arg992 being crucial for this interaction. Replication Protein A (RPA) binds specifically to excision repair proteins XPA and XPG.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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