Thermo Fisher Scientific Azurocidin Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Target Information

Azurocidin, also known as heparin-binding protein (HBP), is an inactive homolog of serine proteinases found in granulocytes. Initially recognized for its activity against gram-negative bacteria, it was later found to act against gram-positive bacteria and Candida albicans.
Azurocidin is a member of polymorphonuclear leukocyte-derived antimicrobial proteins such as defensins, LL-37, and lysozyme. It plays a role in immune response activation and modulation, acting as an alarm molecule for the immune system.
The cationic domain is essential for antimicrobial activity, and the protein is stored in azurophil and secretory granules, released early during extravasation.
Azurocidin contributes to chemotaxis and activation of monocytes, cytokine release, and phagocytosis, enhancing bacterial clearance.
It primarily interacts with endothelial cells and the extravascular environment via beta 2-integrins. Elevated plasma levels of azurocidin may help identify patients at risk of developing sepsis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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