Thermo Fisher Scientific RNF7 Polyclonal Antibody
RNF7 단백질을 인식하는 Thermo Fisher Scientific의 염소 유래 폴리클로날 항체. Western blot과 IHC(파라핀)에서 검증됨. 인간 반응성 및 마우스 반응 예측. 액상 형태, 0.5 mg/mL 농도, -20°C 보관. 세포주기 및 신호전달 연구용.
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- PA519233
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- pk
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Thermo Fisher Scientific RNF7 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–3 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (DACLRCQAENKQE) corresponding to internal amino acids of RNF7 (aa 59–72) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10984564 |
Product Specific Information
- This antibody is predicted to react with mouse based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 8,000.
Target Information
The RNF7 gene encodes a highly conserved ring finger protein that functions as an essential subunit of the SKP1-cullin/CDC53-F box protein ubiquitin ligases complex. This complex plays a key role in protein degradation, cell cycle progression, and signal transduction.
RNF7 interacts with casein kinase II (CSNK2A1/CKII) and is phosphorylated by CSNK2A1, which promotes degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1 (CDKN1B).
Alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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