Thermo Fisher Scientific Phospho-PKC delta (Ser645) Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Positive test controls include: 293T
• Target localization: Cell membrane, Cytoplasm, Endoplasmic reticulum, Mitochondrion, Nucleus, Peripheral membrane protein, Perinuclear region
• Immunogen sequence: RLSYS

Target Information

The PKC family of serine/threonine kinases, including PRKCD (PKC delta), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action, response to extracellular signals, and substrate specificity.
PKC alpha, beta I, beta II, and gamma form the conventional family; their activities are Ca²⁺- and phospholipid-dependent. Protein kinase C (PKC) can be activated by calcium and diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are involved in diverse cellular signaling pathways. They also serve as major receptors for phorbol esters, a class of tumor promoters.
Each PKC family member has a specific expression profile and distinct cellular roles. Studies in humans and mice show that PKC delta participates in B cell signaling and regulates cell growth, apoptosis, and differentiation. Alternatively spliced transcript variants encoding the same protein have been observed.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.