Thermo Fisher Scientific ZIP1 Polyclonal Antibody
ZIP1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC에 적합하며, 인간 및 생쥐 시료 반응성. 항원 친화 크로마토그래피로 정제된 액상 항체로, 암 연구 및 ZIP1 발현 분석에 활용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1–2 µg/mL
Immunohistochemistry (IHC)
- Tested Dilution: 2.5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 16 amino acid peptide near the amino terminus of human ZIP1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11156792 |
Product Specific Information
- Suggested positive control: Mouse kidney tissue lysate
- PA5-21066 can be used with blocking peptide PEP-1180.
Target Information
ZIP1, also known as ZIRTL (zinc-iron regulated transporter-like), is the first mammalian member of a family of divalent ion transporters. Zinc is an essential ion for cellular growth, development, and differentiation.
ZIP1 expression is markedly downregulated in various cancerous tissues and is thought to function as a tumor suppressor gene in prostate cancer.
Overexpression of ZIP1 and increased intracellular zinc in PC-3 cells inhibit NF-kappa-B activity, leading to downregulation of antiapoptotic proteins (Bcl-2, Bcl-XL, XIAP) and reducing the malignant potential of prostate cancer cells in vitro and in vivo.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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