Thermo Fisher Scientific ARHGAP24 Polyclonal Antibody
Human ARHGAP24 단백질을 인식하는 Rabbit Polyclonal 항체. IHC(P) 검증 완료, 1:50–1:200 희석 권장. 항원 친화 크로마토그래피로 정제된 액상 항체로, PBS(40% glycerol) 내 보관. 세포 극성 및 세포골격 조절 연구에 적합.
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Applications
Tested Application
- Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human ARHGAP24. Recombinant protein control fragment (Product # RP-89843) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2638144 |
Product Specific Information
Immunogen sequence:
ILNSDTLGNP TNVRNMSWLP NGYVTLRDNK QKEQAGELGQ HNRLSTYDNV HQQFSMMNLD DKQSIDSATW STSSCEISLP ENSNSCRSST TTCPEQDFFG GNFEDPVLDG PPQDDLSHPR DYESKSD
- Highest antigen sequence identity to orthologs:
- Mouse: 88%
- Rat: 90%
Target Information
Rho GTPase-activating protein involved in cell polarity, cell morphology, and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho, leading to suppression of leading-edge protrusion and promotion of cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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