Thermo Fisher Scientific ARHGAP24 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human ARHGAP24. Recombinant protein control fragment (Product #RP-89843). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:ARHGAP24,uniProtId:Q8N264-1,ncbiNodeId:9606,antigenRange:486-612,antigenLength:748,antigenImageFileName:PA5-53140_ARHGAP24_Q8N264-1_Rabbit.svg,antigenImageFileNamePDP:PA5-53140_ARHGAP24_Q8N264-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2638144

Product Specific Information

Immunogen sequence: ILNSDTLGNP TNVRNMSWLP NGYVTLRDNK QKEQAGELGQ HNRLSTYDNV HQQFSMMNLD DKQSIDSATW STSSCEISLP ENSNSCRSST TTCPEQDFFG GNFEDPVLDG PPQDDLSHPR DYESKSD

Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 90%.

Target Information

Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.