Thermo Fisher Scientific SLC4A4 Polyclonal Antibody
Thermo Fisher Scientific의 SLC4A4 Polyclonal Antibody는 인간, 마우스, 랫트에 반응하며 Western blot, ICC/IF, ELISA에 적합합니다. 합성 펩타이드 면역원 기반으로 제작된 고순도 항체로, 액상 형태이며 -20°C 보관이 필요합니다. 연구용으로만 사용됩니다.
- 카탈로그번호
- PA592401
- 판매단위
- pk
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to amino acids 978–1078 of human SLC4A4 / NBC (NP_0010919541) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.92 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2806475 |
Product Specific Information
- Positive Samples: 293T
- Cellular Location: Basolateral cell membrane, Multi-pass membrane protein
- Immunogen sequence:
VMILALVAVR KGMDYLFSQH DLSFLDDVIP EKDKKKKEDE KKKKKKKGSL DSDNDDSDCP YSEKVPSIKI PMDIMEQQPF LSDSKPSDRE RSPTFLERHT S
Target Information
SLC4A4 encodes a sodium bicarbonate cotransporter (NBC) involved in the regulation of bicarbonate secretion, absorption, and intracellular pH. It functions as an electrogenic transporter with a Na(+):HCO3(-) stoichiometry of 1:2 to 1:3. SLC4A4 regulates bicarbonate influx/efflux at the basolateral membrane and intracellular pH. Isoform 2 may exhibit higher activity than isoform 1. Mutations in SLC4A4 are associated with proximal renal tubular acidosis and ocular abnormalities. Multiple transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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