Thermo Fisher Scientific MUC1/CA15-3/EMA/CD227 (Epithelial Marker) Monoclonal Antibody (Mc5)
인간 MUC1/CA15-3/EMA/CD227 표적 단백질을 인식하는 Mc5 클론 단일클론 항체. 다양한 면역분석(WB, IHC, ICC, Flow)에 사용 가능. 비결합형 액상 형태로 제공되며, 고순도 Protein A/G 정제. 연구용 전용 제품으로 -20°C 보관 권장.
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Thermo Fisher Scientific MUC1/CA15-3/EMA/CD227 (Epithelial Marker) Monoclonal Antibody (Mc5)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | Mc5 |
| Immunogen | Delipidated human milk fat globules |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
MUC1 (Mucin 1, Episialin, MAM-6, CA 15-3, PEM, and EMA) is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages.
It is a transmembrane glycoprotein with a large mucin-like extracellular domain that matures through intermediate forms generated by proteolysis and sequential addition of numerous O-linked glycans.
MUC1 is highly polymorphic, with alleles encoding products containing 30–90 repeats, leading to large molecular weight differences.
It is abundantly expressed in >90% of breast carcinomas and metastases.
Transgenic MUC1 associates with all four cebB receptors and localizes with erbB1 (EGFR) in lactating glands.
The MUC1 gene contains seven exons and produces several alternatively spliced variants.
Overexpression, aberrant localization, and altered glycosylation of MUC1 are associated with carcinomas.
Multiple spliced transcript variants encoding different isoforms have been reported.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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