Thermo Fisher Scientific UFD1L Recombinant Rabbit Monoclonal Antibody (7K8E2)
UFD1L 단백질을 인식하는 토끼 단클론 항체로, Western blot 및 ELISA에 적합합니다. 인간, 마우스, 랫트 반응성이 있으며 HEK293 세포에서 발현된 재조합 항체입니다. Protein A 정제, PBS/glycerol 저장 버퍼, -20°C 보관.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
ELISA
- Tested Concentration: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 7K8E2 |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 1–100 of human UFD1L |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.4 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS (pH 7.3), 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
Product Specific Information
Immunogen Sequence:
MFSFNMFDHP IPRVFQNRFS TQYRCFSVSM LAGPNDRSDV EKGGKIIMPP SALDQLSRLN ITYPMLFKLT NKNSDRMTHC GVLEFVADEG ICYLPHWMMQ
Target Information
Ubiquitin-mediated proteolysis requires the transfer of ubiquitin (Ub) to lysine groups on selected cellular proteins, facilitating degradation by the 26S proteasome. Ub-fusions are cleaved by Ub-specific proteases (UBps) or through the Ub-fusion degradation (UFD) pathway.
UFD1 was first characterized in yeast and later identified in humans as UFD1L. It modulates degradation of Ub-fusions with amino acid substitutions at Gly76 by promoting selective multiubiquitination.
Mutations in the UFD1 gene are associated with CATCH22 syndrome, which includes cardiac defects, cleft palate, and hypocalcemia, suggesting a role in developmental processes.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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