Thermo Fisher Scientific SENP6 Polyclonal Antibody

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human SENP6 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:SENP6,uniProtId:Q9GZR1-1,ncbiNodeId:9606,antigenRange:216-364,antigenLength:1112,antigenImageFileName:PA5-55067_SENP6_Q9GZR1-1_Rabbit.svg,antigenImageFileNamePDP:PA5-55067_SENP6_Q9GZR1-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2647119

Product Specific Information

Immunogen sequence: PTPPLSPASK KCLTHLEDLQ RNCRQAITLN ESTGPLLRTS IHQNSGGQKS QNTGLTTKKF YGNNVEKVPI DIIVNCDDSK HTYLQTNGKV ILPGAKIPKI TNLKERKTSL SDLNDPIILS SDDDDDNDRT NRRESISPQP ADSACSSPA

Highest antigen sequence identity to the following orthologs: Mouse - 69%, Rat - 71%.

Target Information

Ubiquitin-like molecules, such as SUMO1, are structurally related to ubiquitin. and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1. to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins. SENPs also display isopeptidase activity for deconjugation of SUMO-conjugated substrates.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.