Thermo Fisher Scientific SENP6 Polyclonal Antibody
Rabbit polyclonal antibody against Human SENP6 recombinant protein. Unconjugated, liquid form at 0.3 mg/mL concentration. Suitable for research use in studies of SUMO-specific protease activity. Stable at 4°C short term and -20°C long term.
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Thermo Fisher Scientific SENP6 Polyclonal Antibody
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human SENP6 (UniProt ID: Q9GZR1-1, antigen range: 216–364, antigen length: 1112) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2647119 |
Product Specific Information
Immunogen sequence:
PTPPLSPASK KCLTHLEDLQ RNCRQAITLN ESTGPLLRTS IHQNSGGQKS QNTGLTTKKF YGNNVEKVPI DIIVNCDDSK HTYLQTNGKV ILPGAKIPKI TNLKERKTSL SDLNDPIILS SDDDDDNDRT NRRESISPQP ADSACSSPA
Ortholog sequence identity:
- Mouse: 69%
- Rat: 71%
Target Information
Ubiquitin-like molecules, such as SUMO1, are structurally related to ubiquitin and can be ligated to target proteins similarly. However, covalent attachment of UBLs does not lead to degradation of modified proteins. SUMO1 modification is involved in targeting RANGAP1 to the nuclear pore complex and stabilizing I-kappa-B-alpha from proteasomal degradation.
Like ubiquitin, UBLs are synthesized as precursor proteins requiring removal of tail sequences by UBL-specific proteases such as SENP6 before conjugation to target proteins. SENPs also exhibit isopeptidase activity for deconjugation of SUMO-conjugated substrates.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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