Thermo Fisher Scientific Phospho-VAMP4 (Ser30) Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human VAMP4 (Phospho-Ser30) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:VAMP4,uniProtId:O75379-1,ncbiNodeId:9606,antigenRange:20-39,antigenLength:141,antigenImageFileName:PA5-64540_VAMP4_O75379-1_Rabbit.svg,antigenImageFileNamePDP:PA5-64540_VAMP4_O75379-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2662191

Product Specific Information

Phospho-VAMP4 (Ser30) Polyclonal Antibody detects endogenous levels of VAMP4 only when phosphorylated at Ser30.

Target Information

The vesicle associated membrane proteins (VAMP) or synaptobrevins are calcium binding proteins specific to eukaryotes. VAMPs, along with synaptosomal associated protein of 25 kDa (SNAP-25) and syntaxin, form the core complex of soluble NSF attachment protein receptor (SNARE) proteins that interact with the soluble proteins N-ethylmaleimide-sensitive factor (NSF) and alpha-SNAP. These membrane associated proteins play a key role in the regulation of vesicle membrane fusion with the plasma membrane. The Clostridium tetani neurotoxin is a metalloprotease with specificity for VAMP. In Alzheimer`s disease, VAMP levels of all isoforms appear to be significantly lowered.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.