Thermo Fisher Scientific ATRX Monoclonal Antibody (8B2H9)
ATRX 단백질을 인식하는 Mouse IgG1 단클론 항체로 Western Blot과 ELISA에 적합합니다. 정제된 인간 ATRX 재조합 단편(AA 2311-2492)을 면역원으로 사용하였으며, Protein G로 정제된 액상 형태입니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- MA531643
- 판매단위
- pk
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 8B2H9 |
| Immunogen | Purified recombinant fragment of human ATRX (AA: 2311–2492) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2787267 |
Product Specific Information
MA5-31643 has been tested in indirect ELISA.
Target Information
ATRX encodes a protein that contains an ATPase/helicase domain, and thus belongs to the SWI/SNF family of chromatin remodeling proteins. Mutations in this gene are associated with X-linked mental retardation (XLMR) accompanied by alpha-thalassemia (ATRX) syndrome. These mutations alter DNA methylation patterns, linking chromatin remodeling, DNA methylation, and gene expression in development. ATRX undergoes cell cycle-dependent phosphorylation, regulating nuclear matrix and chromatin association, suggesting its role in gene regulation during interphase and chromosome segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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