Thermo Fisher Scientific GCAP1 Polyclonal Antibody
Thermo Fisher Scientific의 GCAP1 Polyclonal Antibody는 인간 GUCA1A 단백질을 인식하는 토끼 유래 IgG 항체로, IHC(P)에서 1:5,000~1:10,000 희석으로 사용됩니다. 항원 친화 크로마토그래피로 정제되었으며, cGMP 합성 조절 연구에 적합합니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:5,000–1:10,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human GUCA1A. Recombinant protein control fragment (Product #RP-105700). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2789362 |
Product Specific Information
Immunogen sequence:
EYVAALSLVL KGKVEQKLRW YFKLYDVDGN GCIDRDELLT IIQAIRAINP CSDTTMTAEE FTDTVFSKID VNGDGELSLE EFIEGVQKDQ MLLDTLTRSL DLTRIVRRLQ NGEQDEEGAD EAAEAAG
Target Information
Guanylate cyclase-activating protein (GCAP1) is a Ca²⁺-binding protein that upregulates synthesis of cGMP in photoreceptors. Mammalian GCAPs share over 90% sequence similarity, consisting of 201–205 amino acids with three conserved Ca²⁺-binding sites. The GUCA1A gene (GCAP1) is expressed exclusively in the retina.
Mutations such as Tyr99→Cys and Pro50→Leu in GUCA1A are associated with autosomal dominant cone dystrophy and phenotypic variability ranging from mild photophobia to rod-cone dystrophy. These mutations can alter protein stability and susceptibility to protease degradation, potentially contributing to retinal cell mortality.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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