Thermo Fisher Scientific CYB561D2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1–3 µg/mL

Product Specifications

Product Specific Information

• Predicted to react with bovine, canine, mouse, and rat based on sequence homology.
• Tested in Peptide ELISA: antibody detection limit dilution 1:16,000.

Target Information

CYB561D2 (Cytochrome b561 domain-containing protein 2), also known as putative tumor suppressor protein 101F6, is a 222 amino acid highly hydrophobic protein containing six membrane-spanning domains. It localizes to endosomes and the endoplasmic reticulum in the perinuclear region and contains two heme-binding sites that reduce ferric ions.
CYB561D2 is ubiquitously expressed, with the highest levels in lung, liver, and kidney. Expression is abundant in normal lung bronchial epithelial cells but absent in most lung cancers. The CYB561D2 gene maps to human chromosome 3p21.3, a region associated with frequent genetic alterations and allele loss in many cancers.
Exogenous expression of CYB561D2 induces caspase-independent apoptotic and autophagic pathways, leading to synergistic tumor cell death, suggesting its potential as a therapeutic target in cancer treatment.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.