Thermo Fisher Scientific HDAC8 Monoclonal Antibody (OTI5F7), TrueMAB
HDAC8 단백질을 인식하는 Mouse IgG1 단클론 항체로 Western Blot에 최적화됨. 인간 HDAC8(aa 1-243) 재조합 단백질을 면역원으로 사용. 액상 형태, 1 mg/mL 농도, PBS/BSA/glycerol buffer에 보관. -20°C에서 보관하며 연구용으로만 사용 가능.
- 판매단위
- pk
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5F7 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–243 of human HDAC8 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. Chromatin remodeling is critical for transcriptional regulation and is largely mediated by histone acetylation. Acetylation of lysine residues in histone tails increases DNA accessibility to transcription factors, while deacetylation is associated with transcriptional silencing.
HDAC8, a mammalian histone deacetylase isolated from human kidney, shares homology with other HDACs but exhibits unique tissue distribution. It localizes to the nucleus and is implicated in tissue development and cancer etiology.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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