Thermo Fisher Scientific TRAF1 Polyclonal Antibody
Human TRAF1 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB 및 IHC(P) 응용에 적합. 항원 친화 크로마토그래피로 정제되었으며, 액상 형태로 제공. 연구용으로 TNF 수용체 신호전달 및 항아폽토시스 연구에 활용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 0.04–0.4 µg/mL
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human TRAF1. Recombinant protein control fragment (Product #RP-99398). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2789137 |
Product Specific Information
Immunogen sequence:
TQEKAHPEVA EAGIGCPFAG VGCSFKGSPQ SVQEHEVTSQ TSHLNLLLGF MKQWKARLGC GLESGPMALE QNLSDLQLQA AVEVAGDLEV DCYRAPCSES QEELALQHFM KEKLLAELEG KLRVFENIVA VLNKEVEASH LALATSI
Target Information
The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins mediate signal transduction from various receptors of the TNFR superfamily. TRAF1 and TRAF2 form a heterodimeric complex required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. This complex also interacts with inhibitor-of-apoptosis proteins (IAPs), mediating anti-apoptotic signals from TNF receptors. Expression can be induced by Epstein-Barr virus (EBV), and EBV membrane protein 1 (LMP1) interacts with TRAF proteins, linking LMP1-mediated B lymphocyte transformation to TNFR signaling. Three transcript variants encoding two different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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